Harish is a Clinical Pharmacokineticist with 10+ years of rich and sound experience in Clinical Pharmacology, PK/PD Modelling ,POPPK Modelling, PBPK, Preclinical DMPK Knowledge & Medical Writing by working at CRO's and R&D Teams. He has led clinical pharmacology (Phase I/BA/BE/ IIA PoC) studies in terms of study designing, endpoint selection, study result evaluation/ presentation/reviewing CDISCs SDTM and ADAM datasets for regulatory submission. He has provided strategic inputs on dose selection for Phase-I/ IIa trials based on PK/PD modelling efforts for differentiated formulations. He has expertise in performing vascular catheterisation procedure and has successfully established cannulations and PK lab procedures. Harish has gained good experience in PK data analysis& PK/PD Modelling using WinNonlin/Phoenix NLME/NONMEM/MONOLIX/R & R Studio and has in depth understanding of the mathematical methods and algorithms used for PK & POPPK data analysis
VP – Discovery
Shahul is an expert in chemistry and pharmaceutical sciences with nearly 15 years of medicinal chemistry experience in anti-bacterial, anti-malarial and anti-inflammatory drug discovery programs. Shahul was previously Team Leader at AstraZeneca India Pvt. Ltd., where he gained international exposure to drug design, diversity-oriented synthesis, parallel synthesis and new synthetic routes for compounds. Shahul has led several lead generation and lead optimization projects. He has progressed many scaffolds from early hit identification stages to pre-clinical development candidates, combating several challenges such as potency, bacterial cell entry and target engagement, safety and DMPK in parallel, while simultaneously securing intellectual property. Shahul has five patents and has over 20 peer-reviewed publications. Shahul received his doctoral degree in Medicinal Chemistry from BITS Pilani, India.
Vasanthi was previously head of Microbiology at AstraZeneca India, where she led early discovery projects in the search of novel anti-mycobacterial drugs. She jointly led the successful discovery of novel combinations for MDR-TB using an integrated in silico-in vitro- in vivo approach. Vasanthi served as Co-PI on research grants from the Wellcome Trust. She has experience in high through-put cell based screens, assessing vulnerability of drug targets, deciphering mechanisms of action of novel anti-bacterial agents, and setting up in vitro disease models for studying infection. Vasanthi established clinical microbiology based collaborative programs with key reputed hospitals across India. Vasanthi earned her Ph.D. in Microbiology from the Indian Institute of Science.
Nainesh previously led the laboratory research at the Infection Business Unit of Cellworks Research India Pvt. Ltd., located at C-CAMP, National Centre for Biological Sciences, India. He is an experienced Biochemist, Molecular Biologist and a Microbiologist and has worked in the areas of infectious diseases, neurobiology, green-chemistry and biofuels. Nainesh received his Ph.D. at the University of Hamburg, Germany and post-doctoral training at the University of Konstanz, Germany in the area of neuronal development and regeneration. He has a patent and multiple publications in international journals to his credit.
Principal Scientist, Computational Chemistry
Nagakumar previously was with St. Jude Children's Research Hospital, Nanyang Technological University, and GVK Biosciences. Kumar is a Computational Medicinal Chemist with expertise in Structure-/Ligand-based drug discovery and Drug repurposing by applying a variety of methods based on available data such as Consensus Pharmacophore based models, Protein-ligand interaction fingerprints, Molecular docking and clustering of poses, High throughput Short MD simulations for filtering false positives, Virtual screening for scaffold hopping and Evaluation of known Off-targets, Binding free energy calculations for Protein-ligand complexes and Quantitative structure activity relationships (QSAR). Nagakumar received his Ph.D. degree from Gyeongsang National University, Korea in Computer aided drug design.