Publications
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The conundrum of bacteria-specific antibiotics
Santanu Datta
Journal of Antimicrobial Chemotherapy
Identification of key amino acid residues in OqxB mediated efflux of fluoroquinolones using site-directed mutagenesis
Purnendu Bhowmik, Nagakumar Bharatham, Satoshi Murakami, Vasanthi Ramachandran, and Santanu Datta.
Research in Microbiology
Validated In Silico Population Model of Escherichia coli
Sreenath Rajagopal, Rothangmawi Victoria Hmar, Debdatto Mookherjee, Arindam Ghatak, Anirudh P. Shanbhag, Nainesh Katagihallimath, Janani Venkatraman, Ramanujan KS, and Santanu Datta
ACS Synthetic Biology
Industrial light at the end of the Iron-containing (group III) alcohol dehydrogenase tunnel
Anirudh P Shanbhag, Arindam Ghatak, Sreenath Rajagopal
Biotechnology and Applied Biochemistry
Validated In Silico Model for Biofilm Formation in Escherichia coli
Purnendu Bhowmik, Sreenath Rajagopal, Rothangamawi Victoria Hmar, Purnima Singh, Pragya Saxena, Prakruthi Amar, Teby Thomas, Rajani Ravishankar, Savitha Nagaraj, Nainesh Katagihallimath, Ramanujan Kadambi Sarangapani, Vasanthi Ramachandran, and Santanu Datta
ACS Synthetic Biology
BSAC Vanguard Series: The future of drug development and the tension between access and excess
Santanu Datta
Journal of Antimicrobial Chemotherapy
Azaindole Based Potentiator of Antibiotics against Gram-Negative Bacteria
Sreevalli Sharma, Ranga Rao, Stephanie M. Reeve, Gregory A. Phelps, Nagakumar Bharatham, Nainesh Katagihallimath, Vasanthi Ramachandran, Savitha Raveendran, Maitrayee Sarma, Anubha Nath, Teby Thomas, Dhanasekaran Manickam, Savitha Nagaraj, V. Balasubramanian, Richard E. Lee, Shahul Hameed P, and Santanu Datta
ACS Infectious Diseases
Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae
Nagakumar Bharatham, Purnendu Bhowmik, Maho Aoki, Ui Okada, Sreevalli Sharma, Eiki Yamashita, Anirudh P. Shanbhag, Sreenath Rajagopal, Teby Thomas, Maitrayee Sarma, Riya Narjari, Savitha Nagaraj, Vasanthi Ramachandran, Nainesh Katagihallimath, Santanu Datta & Satoshi Murakami
Nature Communications volume 12, Article number: 5400 (2021)
Learnings from past failures: Future routes of antimicrobial drug discovery
Santanu Datta
Drug Discov Today, 2021 Jul 24; S1359-6446(21)00323-8.
doi: 10.1016/j.drudis.2021.07.017
Functional characterization of the efflux pump OqxAB by complementation assays in E. coli. Gordon Research Conference 2019
Purnendu Bhowmik, Anirudh P Shanbhag, Nagakumar
Bharatham and Nainesh Katagihallimath.
Multi-Drug Efflux Systems. Lucca, Italy.
In Vitro Activity of BWC0977 (a Novel Bacterial Topoisomerase Inhibitor) and Comparators against Recent Clinical and Molecularly Characterized Enterobacteriaceae and Non-Fermenter Isolates from the United States and Europe
Michael D. Huband, Jill M. Lindley, Amy A. Watters, Holly K. Becker, Vasanthi Ramachandran, V. Balasubramanian, Robert K. Flamm.
ECCMID 2019, Amsterdam. Poster #P1847.
In vitro Activity of BWC0977, a Novel Bacterial Topoisomerase Inhibitor, against Molecularly Characterized Enterobacteriaceae & Non-Fermenter Isolates of the CDC collection and key Biodefense Pathogens
Nathan P. Wiederhold, Maria McElmeel, Thomas F. Patterson, Richard A.
Slayden, Jason E. Cummings, Vasanthi Ramachandran, Shahul Hameed and V. Balasubramanian
ECCMID 2019, Amsterdam. Poster #P1845.
In Vitro Activity of BWC0977 (a Novel Bacterial Topoisomerase Inhibitor) and Comparators against Recent Clinical Enterobacteriaceae and Non-Fermenter Isolates from two hospitals in Bengaluru, India
Savitha Raveendran, Teby Thomas, Maitrayee Sharma, Sreenath Rajagopal, Savitha Prabhumurthy, Savitha Nagaraj, Swathi Purighalla, Vijay Samuel Richard, Shahul Hameed, V.Balasubramanian and Vasanthi Ramachandran.
ECCMID 2019, Amsterdam. Poster #P1845.
BWC0977, a novel dual target topoisomerase inhibitor: antimicrobial potency, spectrum and mechanism of action
Shahul Hameed, Sreevalla Sharma, Radha Nandishaiah, Nainesh Katagihallimath, Nagakumar Bharatham, Aniriudh Shanbhag, Sreenath Rajagopal, Purnendu Bhowmik, Prakruthi Amar, Riya Narjari, Vasanthi Ramachandran, Santanu Datta & V.
Balasubramanian
ECCMID 2019, Amsterdam. Poster #P1844.
A strategy to identify a ketoreductase that preferentially synthesizes pharmaceutically relevant (S)-alcohols using whole-cell biotransformation.
Saiful F. Haq, Anirudh P. Shanbhag, Subbulakshmi Karthikeyan, Imran Hassan, Kannan Thanukrishnan, Abhishek Ashok, Sunilkumar Sukumaran, S. Ramaswamy, Nagakumar Bharatham, Santanu Datta, Shalaka Samant & Nainesh Katagihallimath
– Microbial Cell Factories volume 17, Article number: 192 (2018)
Anti-microbial susceptibility of recent clinical isolates against fluoroquinolones, ceftazidime, meropenem and a novel anti-bacterial drug candidate
Teby Thomas, Maitrayee Sharma, Sreenath Rajagopal, V. Balasubramanian, Savitha Nagaraj and Vasanthi Ramachandran
Microcon 2018, Bengaluru, India.
Anti-microbial sensitivity profiles of WHO identified Priority pathogens against fluoroquinolones, ceftazidime, meropenem and a novel anti-bacterial drug candidate
Savitha Raveendran, Savitha P, Swathi Purighalla, Vijay Samuel Richard, Sreenath Rajagopal, V.Balasubramanian & Vasanthi Ramachandran
Microcon 2018, Bengaluru, India.
Identification and Optimization of Broad Spectrum Novel Bacterial Topoisomerase Inhibitors (NBTIs): Anti-Microbial Potency and Mechanism of Action (BWC0977)
Shahul Hameed P, Radha Nandishaiah*, Nagakumar Bharatham, Nainesh Katagihallimath, Sreevalli Sharma, Anirudh Shanbhag, Sreenath Rajagopal, Teby Thomas, Riya Narjari, Maitrayee Sarma, Savitha Raveendran, Savitha Prabhumurthy, Prakruthi Amar, Purnendu Bhowmik,Vasanthi Ramachandran, Santanu Datta, and V. Balasubramanian
A Broad Spectrum Novel Bacterial Topoisomerase Inhibitor (NBTI): Killing Kinetics, ADME and in vivo Efficacy
Shahul Hameed P, Sreevalli Sharma*, Nainesh Katagihallimath, Ramesh Jayaraman and V. Balasubramanian.
Poster presentation at ASM Microbe 2018 conference, 8th June, Atlanta, GA.
Combating Anti-Microbial Resistance: A Novel Class Effective Against ESKAPE Pathogens
Shahul Hameed P, Sreevalli Sharma, Nagakumar Bharatham, Radha Nandishaiah, Anirudh Shanbhag, Nainesh Katagihallimath, Teby Thomas, Rajani Ravishankar, Riya Narjari, Maitrayee Sarma, Savitha Raveendran, Savitha Prabhumurthy, Prakruthi Amar, Purnendu Bhowmik, Purnima Singh, Vasanthi Ramachandran, R. Jayaraman, Santanu Datta, V. Balasubramanian
Poster Presentation at Keystone Symposia conference on Antimicrobials and Resistance: Opportunities and Challenges, October 29th November 1, 2017 in Santa Fe, New Mexico USA.
Heterocyclic compounds useful as anti-bacterial agents and method for production
Shahul Hameed, Nagakumar Bharatham, Nainesh Katagihallimath, Sreevalli Sharma, Radha Nandishaiah.
GB2550437A (2017)
Heterocyclic compounds useful as anti-bacterial agents and method for production
Shahul Hameed, Nagakumar Bharatham, Nainesh Katagihallimath, Sreevalli Sharma, Radha Nandishaiah.
WO 2017/199265A1 (2017)
Heterocyclic compounds useful as anti-bacterial agents and method for production
Shahul Hameed, Nagakumar Bharatham, Nainesh Katagihallimath, Sreevalli Sharma, Radha Nandishaiah.
Indian Pat. Appl. (2017), IN 201641017526 A.
Discovery of novel dual-target topoisomerase inhibitors effective as broad-spectrum agents: ADME and anti-microbial efficacy
Shahul Hameed, Sreevalli Sharma, Nainesh Katagihallimath, Ramesh Jayaraman, & V. Balasubramanian.
Poster Presentation at ASM/ESCMID Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance, September 6 – 8, 2017 in Boston, Massachusetts, USA
Delineating Substrate Diversity of Disparate Short-Chain Dehydrogenase Reductase from Debaryomyces hansenii
Ghatak A, Bharatham N, Shanbhag AP, Datta S, Venkatraman J (2017).
PLoS ONE 12(1): e0170202. doi:10.1371/journal.pone.0170202
Heterocyclic compounds, method for production and uses thereof
Shahul Hameed, Nagakumar Bharatham, Nainesh Katagihallimath, V. Balasubramanian, Santanu Datta.
Indian Pat. Appl. (2016), IN 2015CH01426 A
Population Level Modeling of Genetic Regulation of Biofilms
K. S. Ramanujan & Santanu Datta.
Poster presented at BIOFILMS7 Conference, Portugal. 26-28 June, 2016.
Population level modeling of Genetic Regulation of Biofilms
Sreenath Rajagopal*,Prakruthi A, Nainesh K, Varada Anirudan, Santanu Datta, Ramanujan Kadambi S
Workshop “Biofilm Biology to Drug Development” – 2-3 September 2016, SASTRA University, Thanjavur
Project Portfolio
